Original Article

Year : 2021 | Volume : 5 | Issue : 2 | Page : 49 - 53

Precursor lesions of gastric carcinoma: A histopathological study

Neeraj Dhameja, Devesh Prakash Yadav1, Sunit Kumar Shukla1, V. K. Dixit1

Departments of Pathology and 1 Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Address or correspondence:

Dr. Neeraj Dhameja, Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

E‐mail: neerajkailash147@gmail.com

Abstract

Introduction:

Gastric cancer is common human malignant epithelial tumor associated with Helicobacter pylori infection. H. pylori infection causes chronic active gastritis with progress to precursor lesions such as atrophic gastritis and intestinal metaplasia which can progress to dysplasia and thus carcinoma may develop.

Aim of the Study:

To study precursor lesions associated with different types of gastric carcinoma.

Materials and Methods:

Eighty cases of gastric carcinoma were included in this study which showed adjacent nonneoplastic gastric fragments. Hematoxylin- and eosin-stained slides were studied.

Results:

Intestinal, diffuse, and mixed types of gastric carcinomas were seen in 67.5%, 28.75%, and 3.75% of cases, respectively. H. pylori, chronic gastritis, atrophic gastritis, intestinal metaplasia, and dysplasia were seen in 13.75%, 92.5%, 25%, 43.75%, and 22.5%, respectively.

Conclusions:

In this study, we have described precursor lesions associated with gastric carcinoma as described in the literature in the Indian population.

Keywords: Atrophic gastritis, dysplasia, gastric carcinoma, Helicobacter pylori, intestinal metaplasia

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

How to cite this article:

Dhameja N, Yadav DP, Shukla SK, Dixit VK. Precursor lesions of gastric carcinoma: A histopathological study. Int J Clinicopathol Correl 2021;5:49-53.