Review article

Year : 2022 | Volume : 6 | Issue : 1 | Page : 1 - 8

Saliva: Composition, Functioning and its Diagnostic Implications – A Review

Pawan kumar T. 1 , Pooja Rathore2 , Sujitha S.3 , Rakesh N.4 , Shwetha V.5 ,

Department of Oral Medicine and Radiology, Ramaiah Institute of Applied Sciences, Bangalore, Karnataka, India

Address for correspondence:

Dr. Pavan Kumar T, Department of Oral Medicine and Radiology, Faculty of Dental Sciences, Ramaiah Institute of Applied Sciences, Bangalore, Karnataka, India. E‐mail: drpavant@yahoo.co.in

ABSTRACT

Saliva is considered to be a profound biological fluid that is a collection of lot of components and they have their own features. It contributes in good oral health and helps in maintaining and assisting the oral environment. In addition, there are many advantages to employing saliva as a substrate for diagnostic analysis as its component levels are severely affected in the case of oral and systemic diseases such as xerostomia, salivary gland disorders, diabetes, and autoimmune diseases, radiotherapy, chemotherapy, etc. Also, the ease of the sample collection provides distinctive advantages such as patient compliance, non-invasiveness, easy storage, repeated collection etc. Several advances have been introduced in the past years for the sensitive detection and quantification of a varied biomarkers that are identified in saliva reflecting the human system, using different methods including Mass Spectrometry (MS), Reverse transcription-polymerase Chain Reaction (RTPCR), microarrays, Enzyme-Linked Immuno-Assay (ELISA) etc. In future researches, gap is subsequently closed between the use of salivary fluids and the other biofluids in the diagnostic applications. The salivary samples are found to be much reliable in diagnosis when compared to the serum sample. This article recollects the overview about the multipurpose body fluid in relation to its clinical significance. Key-words: Saliva, Diagnostic, Oral Health, Biomarkers

Key-words: Saliva, Diagnostic, Oral Health, Biomarker

Financial support and sponsorship

Nil

Conflict of Interest

There is no Conflict of interest

How to cite this article: Pawan kumar T., Pooja R, Sujitha S, Rakesh N, & Shwetha V. (2022). Saliva:Composition, Functioning and its Diagnostic Implications - A Review. International Journal of Clinicopathological Correlation, 6(1). https://doi.org/10.56501/intjclinicopatholcorrel.v6i1.35