Case Report

Year : 2019 | Volume : 3 | Issue : 2 | Page : 67 - 69

DNA methylation subtype and H3K27Me3 status of a case of clear‐cell meningioma of the lateral sphenoid wing

Aaron Song Chuan Foo, Bingcheng Wu1, Felix Sahm2, Shilin Wang, Lwin Sein

Department of Surgery, Division of Neurosurgery, National University Hospital, 1 Department of Pathology, National University Hospital,

Singapore, 2 Department of Neuropathology, Institute of Pathology, University Heidelberg, Heidelberg, Germany

Address for correspondence:

Dr. Bingcheng Wu, Department of Pathology, National University Hospital, Singapore.

E‐mail: bing_cheng_wu@nuhs.edu.sg

Abstract

We report a case of lateral sphenoid wing clear-cell meningioma in a 68-year-old male. Clear-cell meningiomas account for 0.2%–0.8% of meningiomas and are notorious for their aggressive clinical behavior. To our surprise, DNA methylation profiling and H3K27Me3 testing suggested an indolent meningioma subtype in our patient’s case. This case illustrates discrepancies between histopathological and molecular-based classification systems and highlights the importance of considering the molecular profile of tumors during prognostication.

Keywords: Clear-cell meningioma, DNA methylation, H3K27me3

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

How to cite this article:

Foo AS, Wu B, Sahm F, Wang S, Sein L. DNA methylation subtype and H3K27Me3 status of a case of clear-cell meningioma of the lateral sphenoid wing. Int J Clinicopathol Correl 2019;3:67-9.