Case Report

Year : 2021 | Volume : 5 | Issue : 2 | Page : 85 - 87

Proliferative struma ovarii: A rare case report

Shankhanila Mazumdar, Gagan Kumar Rangari, Neeraj Dhameja, Nisha Rani Agrawal1

Departments of Pathology and 1 Obstetrics and Gynaecology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Address for correspondence:

Dr. Gagan Kumar Rangari, Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Semicircle Road Number 4, Varanasi ‐ 221 005, Uttar Pradesh, India.

E‐mail: gagan13690@gmail.com

Abstract

Dermoid cyst is the most common ovarian neoplasm, comprising up to 25% or more of all ovarian tumors, and contains various mature tissues derived from one or more of the embryonic germ layers, the ectoderm, mesoderm, and endoderm but occasionally transform to malignant. Struma ovarii is defined as teratoma containing predominantly thyroid tissue up to 50% of the cases. Stroma ovarii is a very unusual and rare type of teratoma and has been demonstrated in 5%–20% of the cases and comprises 3% of ovarian teratomas. For struma ovarii, patient age ranges between 6 and 74 years and most patients are in their reproductive years. Struma ovarii is predominantly unilateral and associated with mature cystic teratoma, ascites, pleural effusion, and rarely with a cystadenoma. Tumor is composed of mature thyroid tissue comprising varying sizes of follicles lined by columnar or flattened epithelium. Sometimes, the follicles are markedly crowded, but other criteria of malignancy are absent, and hence, these cases are reported as proliferative struma ovarii. Proliferative struma ovarii has a good prognosis. Some benign cases are misdiagnosed as carcinoma when serum CA-125 is highly raised. As there are no specific clinical, radiological, and serological markers available for this rare tumor, these are diagnosed on histopathology.

Keywords: Benign thyroid lesion, germ cell tumor, mature teratoma, proliferative struma ovarii

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Conflicts of interest

There are no conflicts of interest.

How to cite this article:

Mazumdar S, Rangari GK, Dhameja N, Agrawal NR. Proliferative struma ovarii: A rare case report. Int J Clinicopathol Correl 2021;5:85-7.