Case Report
Year : 2018 | Volume : 2 | Issue : 1 | Page : 12 - 14
An unusual cause of osteomalacia – A case report of phosphaturic mesenchymal tumor of the right hip bone
Bingcheng Wu, Joel‐Louis Zongwei Lim1, Fredrik Petersson
Departments of Pathology and 1 Orthopaedic Surgery, National University Hospital, Singapore 119074, Singapore
Address for correspondence:
Dr. Bingcheng Wu, Department of Pathology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
E‐mail: bing_cheng_wu@nuhs.edu.sg
Abstract
Phosphaturic mesenchymal tumor(PMT), while a rare entity, is nevertheless an important cause of oncogenic malacia/tumor‐induced osteomalacia (TIO). We present a case of PMT. Our 47‐year‐old patient presented with unexplained osteomalacia refractory to medical therapy, associated with left subtrochanteric stress fracture. Further workup revealed the presence of a tumor in the left anterior inferior iliac spine, which was subsequently excised. Histopathology of the tumor showed the characteristic features of PMT, including grungy calcifications, osteoclast‐type multinucleated giant cells, and bland round‐to‐spindled tumor cells. Following excision of the PMT, the patient’s osteomalacia swiftly resolved. PMT is an important differential diagnosis in the context of oncogenic osteomalacia/TIO. As highlighted by our case report, PMT has fairly characteristic clinical and histopathologic features. However, given its rarity, an awareness of this entity is required for correct diagnosis and treatment.
Keywords: Fibroblast growth factor‐23, oncogenic osteomalacia, phosphaturic mesenchymal tumor, tumor‐induced osteomalacia
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
How to cite this article:
Wu B, Lim JL, Petersson F. An unusual cause of osteomalacia – A case report of phosphaturic mesenchymal tumor of the right hip bone. Int J Clinicopathol Correl 2018;2:12-4.
