Review Article

Year : 2019 | Volume : 8 | Issue : 1 | Page : 1-5

Cellular Senescence due to Physical Inactivity: A Review

Sangavi Ramesh, Abilasha Ramasubramanian, Suganya Panneer Selvam

Department of Oral Pathology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, Tamil Nadu, India

Address for correspondence:

Dr. Suganya Panneer Selvam, Department of Oral Pathology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, Tamil Nadu, India. E-mail: drsugan29@gmail.com

Abstract

Fundamental building blocks of our bodies are called as cells. Cellular changes play a major role in the ageing process. Cellular senescence is a process where there is inability of the cells to proliferate due to loss of replicative or growth potential. Physical inactivity is the absence of any movement produced by muscles of body, which requires energy. Various molecular mechanisms are responsible for cellular senescence. One important factor is telomere, which protects chromosome and is chiefly responsible for the replicative process. Physical activity is found to be associated with reduced disease risk and increased longevity through various cellular and molecular mechanisms. However, evidences relating to cellular senescence and physical inactivity are found in sparse. This review aims to discuss the importance of physical activity and role of telomere in senescence and other aging processes.

Keywords: Cellular senescence, chromosome, exercise, replication, telomeres

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

How to cite this article:

Ramesh S, Ramasubramanian A, Selvam SP. Cellular senescence due to physical inactivity: A review. Int J Histopathol Interpret 2019;8:1-5.