Case Report

Year : 2023 | Volume : 7 | Issue : 1 | Page : 27-31

Adamantinomatous Craniopharyngioma-A rare Tumor arising from remnant of Rathkes pouch

1Postgraduate, Department of Pathology, Saveetha Medical College and Hospital, Saveetha Nagar, Thandalam, Chennai 602105, Tamil Nadu, India. 2 Postgraduate, Department of Pathology, Saveetha Medical College and Hospital, Saveetha Nagar, Thandalam, Chennai 602105, Tamil Nadu, India. 3Professor, Department of Pathology, Saveetha Medical College and Hospital, Saveetha Nagar, Thandalam, Chennai 602105, Tamil Nadu, India,

Address for Correspondence:

Dr. Sunderesh Kamal Chander . U

Postgraduate, Department of Pathology, Saveetha Medical College and Hospital, Saveetha Nagar, Thandalam, Chennai 602105, Tamil Nadu, India.

Email Id – sundereshmbbs@gmail.com

Abstract

Craniopharyngioma is a rare tumor arising from squamous rests located at any point along the invagination of the primitive stomodeum, Rathke’s pouch, from the nasopharynx to the hypothalamus. 1 There are two peaks in the occurrence of adamantinomatous craniopharyngioma, one in the first to second decade and the other in the fifth decade. They are generally sporadic and their molecular pathogenesis is poorly defined. There are two clinicopathological forms of craniopharyngiomas-papillary squamous type, and adamantinomatous craniopharyngioma. The classical adamantinomatous variant, which affects people of all ages consists of palisading columnar cells that look like ameloblast of embryonic tooth buds. It has poor prognosis when compared to papillary craniopharyngioma. It has an underlying mutation in β-catenin and translocation of the protein to the nucleus, which can be demonstrated by immunohistochemistry.

Keywords: craniopharungioma, adamantinomatous, poor prognosis, β Catenin.

Conflict of Interest

There is no conflict of interest.

Financial support and sponsorship

Nil

How to cite this article: Vanishree Murugavel, Sunderesh Kamal Chander, & Sonti Sulochana. (2023). Adamantinomatous Craniopharyngioma-A rare Tumor arising from remnant of Rathkes pouch: Case Report. International Journal of Orofacial Biology, 7(1), 27–31. https://doi.org/10.56501/intjorofacbiol.v7i1.814