Review Article

Year : 2019 | Volume : 3 | Issue : 2 | Page : 40 - 41

Chemokines and Interleukins – The Chemodirectors of Immunity

Mudiyayirakkani Muthusamy

Department of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, Tamil Nadu, India

Address for correspondence:

Dr. Mudiyayirakkani Muthusamy,

Department of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Saveetha University, Chennai, Tamil Nadu, India.

E-mail: drmudiyayirakkanimuthusamy95@gmail.com

Abstract

Chemokines are tiny proteins that regulate the movement of cells. In mammals, a large family of these compounds has been identified, with almost 50 members. There are four groups within this family, each distinguished by the spacing of two N-terminal cysteines, which form disulphide bonds with two other cysteine residues to generate the tertiary structure that chemokines are known for. Interleukins (IL) are a type of cytokine that was once considered to be produced only by leukocytes but has now been discovered to be produced by a variety of different bodily cells. They are involved in immune cell activation and differentiation, as well as proliferation, maturation, migration, and adhesion. They have anti-inflammatory and pro-inflammatory effects as well. Interleukins' major function is to control growth, differentiation, and activation during inflammatory and immunological reactions. Interleukins are a wide category of proteins that connect to high-affinity receptors on cell surfaces and can cause a variety of responses in cells and tissues. They work in both a paracrine and autocrine manner.

Keywords: chemokines, interleukins, immunefactors

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

How to cite this article:

Muthusamy M. Chemokines and interleukins – the chemodirectors of immunity. Int J Orofac Biol 2019;3:40-1.