Original Article
Year : 2022| Volume : 6 | Issue : 2 | Page : 28-38
Omics’ in oral cancer: A comprehensive review
Manisha A Sardar, MDS1*| Sanpreet S Sachdev, MDS 1* | Jagdish V Tupkari, MDS 1* | Shubhangi Dalvi, MDS 2* | Tabita J Chettiankandy, MDS 1*| Zaneta D’ Souza, MDS 3*
1Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Mumbai-400001, India , 2 Department of Biochemistry, Grant Government Medical College and Hospital, Mumbai-400001, India, 3 Department of Oral Pathology and Microbiology, Nair Hospital and Dental College, Mumbai, India.
Correspondence :
Sanpreet Singh Sachdev,
Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Mumbai-400001, India
Email: sunpreetss@yahoo.in
Abstract
Health and disease states are dictated or accompanied by corresponding alterations in genes, mRNAs, proteins and metabolites. Over the past few decades, various ‘omic’ technologies have been developed to study the genome, transcriptome, proteome and metabolome respectively. Since oral cancers are one of the leading causes of death globally, much of research work has attempted to study the analytes in cancerous conditions by utilizing the various ‘omic’ modalities. These studies have aimed to understand the pathogenesis of head and neck cancers, aid in their diagnosis, devise new treatment strategies, and improve prognosis. It is imperative for surgeons and pathologists to be in line with the updates pertaining to various ‘omic’ methodologies available for studying the analytes. The present review comprehensively describes the development of various ‘omic’ technologies, including- genomics, transcriptomics, proteomics and metabolomics, while emphasizing their applicability in oral cancers.
K E Y W O R D S: Genomics; Transcriptomics; Proteomics; Metabolomics; Salivaomics
Funding information
Nil
Conflict of interest
The authors have no conflicts of interest to declare.
How to Cite
Sachdev, S. S., Sardar, M. A., Tupkari, J., Chettiankandy, T. J., Dalvi, S., & D’Souza, Z. (2022). Omics’ in oral cancer: A comprehensive review. International Journal of Orofacial Research, 6(2), 28–38. https://doi.org/10.56501/intjorofacres.v6i2.152
