Review Article

Year : 2024 | Volume : 15 | Issue : 2 | Page : 13-25

Self Assembling Peptide P11-4 for management of white spot lesions in subjects undergoing orthodontic treatment

Nazleen Valerie Vas1, Ravindra Kumar Jain2

1-Postgraduate Student, 2-Professor, Department of Orthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, India.

Address for Correspondence:

Dr Ravindra Kumar Jain Professor, Department of Orthodontics, Saveetha Dental College and hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, TamilNadu, India.

Email id:ravindrakumar@saveetha.com

Phone No:+919884729660

Abstract

White Spot Lesions (WSLs) are early signs of enamel demineralization, often occurring during orthodontic treatment due to hindered oral hygiene maintenance. Traditional treatment methods include resin infiltration or remineralization using fluoride-based agents. However, self-assembling peptides (SAPs), such as Curodont ™ Repair (P11-4), have emerged as potential alternatives for WSL management. This review comprehensively examines the chemistry, mode of action, clinical safety, and efficacy of SAP P11-4 in remineralizing enamel lesions. It synthesizes findings from studies investigating SAP P11-4's remineralizing potential using various assessment methods, including pH cycling models, laser fluorescence, digital subtraction radiography, and confocal microscopy. SAP P11-4, with its ability to mimic the enamel matrix and promote hydroxyapatite nucleation, demonstrates promising outcomes in reducing WSL size and progression. Clinical studies report significant improvements in lesion remineralization with SAP P11-4 treatment, often surpassing the efficacy of fluoride-based interventions. Moreover, SAP P11-4 shows compatibility with bonding procedures and potential for reducing dentin hypersensitivity. They offer a promising alternative or adjunct to traditional fluoride-based treatments for WSL management, providing clinicians with a valuable tool in promoting enamel health and preventing caries progression. Further research is warranted to explore long-term outcomes and optimize treatment protocols for maximum efficacy.

CONFLICT OF INTEREST

No conflict of interest among the authors of this study.

SOURCES OF FUNDING

Nil

How to cite this article: Vas, N. V., & Jain, R. K. (2024). Self Assembling Peptide P11-4 for management of white spot lesions in subjects undergoing orthodontic treatment: Review Article. International Journal of Orthodontic Rehabilitation, 15(2), 13–25. https://doi.org/10.56501/intjorthodrehabil.v15i2.1031