Case Report
Year : 2020 | Volume : 3 | Issue : 2 | Page : 20-23
Clear cell odontogenic carcinoma with skeletal metastasis: A rare case report
Minnu Khadeeja, Daphne Fonseca, Chandrasekhara Rao1 , T. S. Rao1
Department of Pathology, Basavatarakam Indo American Cancer Hospital & Research Institute, Hyderabad, Telangana, India, 1
Department of Surgical Oncology, Basavatarakam Indo American Cancer Hospital & Research Institute, Hyderabad, Telangana, India
Address for correspondence:
Dr. Daphne Fonseca, Department of Pathology, Basavatarakam Indo American Cancer Hospital & Research Institute,
Hyderabad 500034, Telangana, India.
E-mail: daf_doc_2005@hotmail.com
Abstract
Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic malignancy with a female preponderance occurring in the adult age group. CCOC was classified as a malignant neoplasm of odontogenic origin by the World Health Organization in 2005 because of its aggressive nature, local recurrence tendency, and the potential for regional and distant metastasis. Histologically, CCOC is characterized by sheets and islands of vacuolated and clear cells. Metastasis at presentation is rare; it usually involves cervical lymph nodes and lungs, less frequently to bone. As clear cells are present in few odontogenic tumors; salivary gland neoplasms; and metastatic tumors to the jaws, especially metastatic renal cell carcinoma, the presence of clear cells in a lesion of the head and neck region poses a diagnostic challenge. So knowledge about the clinical course, histopathological pattern, and immunoprofile of CCOC helps in differentiating the other clear cell tumors.
Keywords: Clear odontogenic carcinoma, differential diagnosis, immunohistochemistry, skeletal metastasis
Financial support and sponsorship
The authors disclosed no funding related to this article.
Conflicts of interest
The authors certify that there is no conflict of interest with any financial organization regarding the material discussed in the manuscript.
How to cite this article: Khadeeja M, Fonseca D, Rao C, Rao TS. Clear cell odontogenic carcinoma with skeletal metastasis: A rare case report. Int J Head Neck Pathol 2020;3:20-3.
