Original Article

Year : 2018 | Volume : 2 | Issue : 1 | Page : 20 -22

Trop2 in Adenoid Cystic Carcinoma: A Pilot Study

L. Pratheepa, Herald J. Sherlin, Anuja Natesan, Priya Premkumar, Pratibha Ramani

Department of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Chennai, Tamil Nadu, India

Address for correspondence:

Dr. L. Pratheepa,

E‑mail: l.pratheepa@gmail.com

Abstract

Background:

Adenoid cystic carcinoma (ACC) is one of the common salivarygl and malignancies with a high recurrence rate and a tendency for perineural invasion. Trop2 is a cell surface glycoprotein expressed in trophoblasts. It is believed to be an oncogenic glycoprotein that plays a role in tumorigenesis. The current study was a maiden attempt to study Trop2 expression in cases of ACC.

Materials and Methods:

Four histopathologically confirmed cases of ACC were subjected to immunohistochemical staining using the Trop2 antibody.

Results:

The staining for Trop2 was negative in all the cases of ACC.

Conclusion:

Trop2 seems to be a molecule with varied functions. Identification of the other pathways that go hand in hand with Trop2 might help us to understand clearly its role in pathogenesis. Such studies might also throw more light on the varied expression pattern of Trop2 in different carcinomas.

Keywords: Adenoid cystic carcinoma, salivary gland neoplasm, Trop2

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

How to cite this article:

Pratheepa L, Sherlin HJ, Natesan A, Premkumar P, Ramani P. Trop2 in adenoid cystic carcinoma: A pilot study. Int J Orofac Biol 2018;2:20-2.