Review Article

Year : 2023 | Volume : 14 | Issue : 3 | Page : 1 - 10

The Effect of Melatonin and Its Agonist on Bone Metabolism: A Scoping Review

Sanjana Thiagarajan1 , Umarevathi Gopalakrishnan2 , Koduri Manoghna3 , R. Balasubramanian4 1,3,4 Post Graduate, 2Professor, Department of Orthodontics and Dentofacial Orthopaedics, Sri Venkateswara Dental College and Hospital, Thalambur, Chennai 600130, India.

Address for Correspondence:

Dr.Umarevathi Gopalakrishnan, MDS., Ph.D.

Professor, Department of Orthodontics and Dentofacial Orthopaedics Sri Venkateswara Dental College and Hospital, Thalambur, Chennai-600130.

Contact: +919841289794.

E-Mail: umarevathigopalakrishnan@gmail.com.

Abstract

Objectives:

To investigate the effects of melatonin and its agonist on bone tissue through a systematic review of literature.

Materials and Methods:

The keywords [Melatonin OR Pineal Hormone OR Ramelteon OR Agomelatine OR Tasimelteon] AND [Bone OR Osteoblast OR Osteoclast OR Bone remodelling OR Bone Metabolism] were searched on Scopus, Web of Science, and PubMed. Title and abstracts were reviewed to exclude the duplicates and irrelevant articles. The full-text articles were then screened in accordance with the inclusion criteria.

Results:

Of the 963 identified articles [PubMed=788, Web of Science=122, Scopus=53], only 3 studies qualified to be included in the systematic review based on the inclusion criteria. The first study assessed effects of the oral melatonin on bone integrity and mass in postmenopausal osteopenic women. Whereas the other two evaluated the radiographic and clinical outcomes of dental implants with the local application of melatonin. All studies showed an improved outcome parameter in comparison with the control group. All three studies elicited a low risk of bias.

Conclusion:

This study suggests that melatonin has osteoinductive potential and has an inhibitory effect on osteoclasts, thereby improving the quality and rate of bone remodelling.

Keywords: Melatonin, Bone remodelling, Pineal hormone, Osteoblast, Osteoclast, Orthodontics.

CONFLICT OF INTEREST

The authors declare no conflict of interest exist.

FUNDING

There are no funding agencies involved in the present study.

How to cite this article: Thiagarajan, S., Gopalakrishnan, U., Manoghna, K., & R, B. (2023). The Effect of Melatonin and Its Agonist on Bone Metabolism: A Scoping Review. International Journal of Orthodontic Rehabilitation, 14(3), 1–10. https://doi.org/10.56501/intjorthodrehabil.v14i3.826